My MTHFR Protocol

I’ve meant to update about MTHFR and my health for so long! I’ve promised it to many and I’m finally sitting down to write it out. I think I arrived at such a better place after it that I forgot to post at all. I guess that’s a pretty good testament to this protocol! 

If you want to know what MTHFR is (and you should, since nearly half of all Americans have it), check out this blog specifically about MTHFR. If you want to follow the journey of discovery and where I came from, see this post about antibiotics & anxiety and this one about Candida and this one about over-methylation.

My discovery of MTHFR began with a bug bite and a prescription that immediately caused panic attacks. It took me months to bounce back from that. I truly believe my discovery of MTHFR helped me to have a successful last pregnancy and a healthy last baby. But I still wasn’t feeling great. 

When I had survived pregnancy, postpartum, baby’s tongue- and lip-ties, and was beginning to feel like a human again, I started to get serious about my symptoms. My most concerning symptom was this undercurrent of jitters. It wasn’t quite like anxiety, but more like a high, fast vibration that I couldn’t subdue. Oh sure, I could self-medicate with wine and I reduced sugar so as not to encourage it, but it was always there. I continued my regimen, but it wasn’t working. 

I met with my NP, who is an expert with MTHFR. She presented me with a protocol that I was nervously excited to begin. She pointed out that my current regimen (which included a Thorne vitamin) was inconsistent for my needs. It was causing my jitters! All throughout my pregnancy and postpartum challenges, my vitamin was actually making things worse. Insert huge sigh here. 

So here is what I did, including affiliate links below. (Purchasing via these links will not affect your price at all, but will contribute a tiny bit to the creation and maintenance of this blog.) 

The First Step:

​I purchased Seeking Health Active B12 5000. Sometimes this isn’t available on Amazon, but I’ve had no problem getting it directly from Seeking Health itself.

I cut a tab in fourths. For one week, I took a quarter of a tab every morning on an empty stomach. I kept careful watch over myself and my jitters. I didn’t feel terrible, but I didn’t feel better either. 

After a week (or maybe 2, because I was scared to increase the dosage), I switched to a half of a tablet. This also seemed to settle pretty well. When you’re hypersensitive to every feeling in your body, thanks to years of anxiety, jitters, and uncertainty, it’s hard to know what’s causing what, but I convinced myself to trust the process. 

The goal is to increase until a dose is uncomfortable and then step back to the previous dose that felt good. I tried off and on for weeks to get to 3/4 of a tablet. I had jitters. I had discomfort. I thought maybe it was a stomach bug one week. Another time I tried, I thought it was PMS messing with me. Or I didn’t get much sleep this week, so that could be it. So many possibilities, but I ended up back at half a tablet every time. 

When I spoke to my NP about it she said it was clear to her that I was a half-er. And that’s ok! I wasn’t necessarily trying to get up to a point of tolerating a whole tablet of B12. I was trying to get up to my perfect dose and for many people a half is just good enough. 

The Next Step: 

Once I was on the dose that worked for me, the next step was to add in Folate. But not just any folate and definitely not folic acid. Methylfolate is the supplement needed since MTHFR prevents my body from being able to break down and absorb folate. I purchased Bluebonnet Earth Sweet Cellular Active Methylfolate 1000 mcg. 

My mornings began with a half of a B12 tablet and a whole methylfolate tablet. And then I waited. Would I feel bad? Would it cause jitters? Would it make things better or worse? 

Let me say that I felt better than I had in years. I felt energized and jitter-free and just so free in my body. I wish I could say that amazing feeling lasted, but I think my body got used to it and the euphoria settled into normalcy. I’m not complaining! I’ll take normal any day. 

I cannot issue medical advice, but I am happy to share my journey and my resources with you. I think this protocol is worth trying if you have or suspect you have MTHFR. MTHFR is SO common and can cause so many issues, including but not limited to: 

  • depression
  • anxiety
  • autism
  • ADHD
  • thyroid disorders
  • autoimmune disorders
  • chronic pain disorders
  • schizophrenia
  • bipolar disorders
  • heart problems
  • fibromyalgia
  • Parkinson’s disease (and other tremor disorders)
  • preeclampsia
  • postpartum depression
  • strokes
  • hormone & fertility problems
  • Alzheimer’s disease
  • migraines

….and many more

If you want to know if you have MTHFR, you can go through your doctor or through 23ndme. If you go through your doctor, you need to ask for both 1298C and 677T, since most doctors will only do 677T. Also, know that your insurance may not cover it. Honestly, it is probably cheaper to use 23andme rather than your insurance. I spent more through insurance getting tested only for MTHFR than I did on one 23andme test that has been able to tell about ALL my genes and gene mutations! Use this link, my personal referral link, to order your 23andme kit and I will help you unlock your raw data to access all your genes and find out if you have MTHFR! https://refer.23andme.com/s/theresasingleton

In peace and health, 
​Theresa